Highway 133 has reopened in both directions near mile marker 63, according to a Pitkin Alert.
The highway was shutdown due to a wildfire around 4 p.m.
Jenny Cutright, deputy chief and public information officer at Carbondale & Rural Fire Protection District, said the five-acre fire is now contained.
Fire crews are working on hot spots and will deploy a water line, a type of fire suppression technique, to make sure the fire does not reignite.
She did not state a cause for the wildfire.
This is a developing story, and it will be updated as more information becomes available.