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No one has been a late-night TV host longer than David Letterman, who retires Wednesday after 33 years. Here's what he told TV Critic Eric Deggans about leaving the Ed Sullivan Theater one last time.

Researchers in Seattle are busy cataloging what scientists have learned. For now that includes detailed information on 240 mouse cells. Next up: a data trove of details on human brain cells.

NYPD officer Peter Liang has been indicted for the death of Akai Gurley. Some in the Asian-American community support holding Liang accountable; others say he is being scapegoated because of his race.

The jury already convicted Boston Marathon bomber Dzhokhar Tsarnaev. Now jurors decide whether he will live or die.

In a tweet sent in the wee hours of Thursday, Shearer said he was leaving "because I wanted what we've always had: the freedom to do other work."

An NTSB board member said that's when the engineer slammed on the brakes to slow it down. The derailment Tuesday in Philadelphia killed eight people. More than 200 were injured.

Ivy Ziedrich, 19, challenged the potential presidential candidate on his assertion that the Sunni extremist group was the result of the U.S. pulling out of Iraq.

The results are out: Fifteen-year-olds who took a skills assessment test had a hard time with it, no matter where they lived. See how you might fare with some sample questions.

Thirteen-year-old Nicholas Heyward Jr. was playing with a toy gun in the stairwell of the housing complex where he lived in Brooklyn when a police officer shot and killed him in 1994.

New charities pop up all the time. But how do you know which ones work? Economists have come up with a strategy to figure it out. They've used it to tackle one of the biggest problems in the world.